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Endocrine Abstracts

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ea0034oc1.1 | Young Endocrinologists prize session | SFEBES2014

The Thr92Ala substitution in deiodonase-2 is associated with increased odds of a sub-optimal IQ score in children with low-normal thyroid function

Taylor Peter , Okosieme Onyebuchi , Sayers Adrian , Northstone Kate , Draman Mohd , Stevenson Kirsty , Woltersdorf Wolf , Taylor Andrew , Pearce Elizabeth , Panicker Vijay , Ludgate Marian , Gregory John , Lazarus John , Timpson Nicholas , Channon Sue , Dayan Colin

Importance: Thyroid hormone is essential for cognitive development. The Thr92Ala substitution in deiodonase-2 appears to reduce intracellular availability of active thyroid hormone. Individuals with low-normal serum thyroid hormone levels and this substitution might have insufficient intracellular thyroid hormone for optimal cognitive development.Objective: To explore whether individuals with low thyroid hormone bioavailability – free thyroxine in t...
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Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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